Physiology and Biophysics Opportunities

Postdoctoral Positions

Postdoctoral training to study ion channel gating mechanisms and the mechanism of transmitter release.
For ion channels our goal is to determine the kinetic gating mechanism of ion channels through structure-function studies and kinetic modeling of mechanism. Techniques include single-channel recording, site directed mutagenesis, and numerical methods. For transmitter release studies our goal is to determine the underlying molecular mechanism of short-term synaptic plasticity. Methods include calcium imaging studies, electrophysiology, and kinetic analysis of changes in transmitter release to develop computer models describing underlying mechanism. Send curriculum vita and list of references to Dr. Karl Magleby, Department of Physiology and Biophysics, by email: kmagleby@miami.edu.

NIH-funded postdoctoral position(s) to identify receptors involved in sensory transduction in taste cells.
Our goal is to identify receptors involved in sensory transduction in taste cells. A strong background in molecular and biochemical techniques (cloning, expression, membrane proteins, signal transduction) is necessary. Join a collaborative team integrating cellular and molecular structure with function in mammalian taste buds. Salary dependent on experience. Send vita and references to Dr. N. Chaudhari, Dept. of Physiology/Biophysics, Univ. Miami. Sch. Med., P.O. Box 016430, Miami, FL 33101, nchaudha@newssun.med.miami.edu

Postdoctoral appointment to study cellular and molecular biology of taste transduction.
A postdoctoral appointment in the field of sensory neurobiology is available to study the cellular and molecular biology of taste transduction. Ongoing research projects utilize a variety of methodologies--patch clamp recording, immunocytochemistry, functional imaging for Ca²⁺, pH and voltage and others--to study events in taste buds (e.g., Huang et al., `05, J. Neurosci.; Chaudhari et al. `96, J. Neurosci.). Send vita and references to Dr. S. Roper, Dept. of Physiology/Biophysics, Univ. of Miami Sch. of Med., P.O. Box 016430, Miami, 33101, sroper@newssun.med.miami.edu

Postdoctoral training to study cellular mechanisms of nerve repair.
A postdoctoral positionis available to work on a NIH funded project that focuses on the role of microglial cells in the repair of the nervous system. The postdoc will study not only the involvement of microglia in nerve repair, but also will examine the signals including nitric oxide (NO) that direct microglia to accumulate at lesions. Techniques and approaches will include high resolution digital imaging in conjunction with pharmacological manipulations, in situ hybridization, immunocytochemistry, and cellular electrophysiology. Much of the work will be done on the nervous system of the leech, which because of its accessibility and capacity for successful repair has been particularly favorable for experimentation. For additional information contact Prof. Kenneth Muller (U. of Miami Neuroscience Program and Department of Physiology & Biophysics) at 305-243-5963 or by email write kmuller@miami.edu.

Postdoctoral training to study neuronal circuits underlying learning and the restoration of function after injury.
An opportunity is available to work on a NIH funded project to determine the cellular mechanisms of neuronal signalling underlying non-associative conditioning. In addition, study mechanisms for repair of neuronal circuits responsible for learning. Postdoctoral scientists can be trained in a wide range of techniques and approaches, including electrophysiological recording from identified neurons, laser microbeam surgery of single axons and dendrites in living animals, confocal and electron microscopy of intracellularly labeled neurons, and behavioral measures. Experiments will use the nervous system of the leech, which because of its identifiable neurons, one of which (the S interneuron) is crucial for non-associative conditioning, has been particularly favorable for studying the cellular basis of behavior. Moreover, our detailed knowledge of neuronal circuitry in the leech and its capacity to repair connections make the leech ideal for studies of synaptic plasticity and synapse regeneration. For additional information contact Prof. Kenneth Muller (U. of Miami Neuroscience Program and Department of Physiology & Biophysics) at 305-243-5963 or by email write kmuller@miami.edu.