Ellen Barrett
Professor |
|
Synaptic transmission at vertebrate motor nerve terminals. Electrical signalling in myelinated axons. Measurement of intracellular ion transients; quantitative simulations to test transmitter release mechanisms |
John Barrett
Professor |
|
How neurotrophic molecules help primary mammalian central neurons survive and withstand environmental stresses. Mechanisms by which mammalian neuronal and endothelial membranes reseal after mechanical injury. |
Laura Bianchi
Assistant Professor |
|
|
Nirupa Chaudhari
Professor |
|
Molecular mechanisms of sensory transduction in mammalian taste buds. cDNA cloning for G-protein coupled-receptors, effector enzymes and ion channels in taste buds; functional expression studies in heterologous cells in culture; functional assays in taste cells using biochemical, electrophysiological and imaging methods. |
Gerhard Dahl
Professor |
|
Identification of functional domains within the molecular subunits of gap junctions, the connexins. Determination of the physiological function of specific gap junction proteins in tissues. Mutation analysis, transgenic mice, voltage clamp, patch clamp. |
Gavriel David
Research Associate Professor |
|
Modulation of transmitter release and endocytosis in motor nerve terminals, neuromuscular junction, intracellular calcium buffering, mitochondrial calcium uptake, ion-sensitive dyes, laser-scanning confocal microscopy, computer modeling and simulation. |
Raul DeGasperi
Professor |
|
Simplify the technique of recording electrocardiograms, especially during cardiac emergencies. Apply basic physiological research done in the last 40 years by Durrer, Spach, Scher and others on the sequence of activation of the heart, to clinical diagnosis. |
Ana Díez-Sampedro
Assistant Professor |
|
|
Robert Keane
Associate Professor |
|
Apoptotic and anti-apoptotic mechanisms after CNS injury. Regulation of caspases and inhibitors of apoptosis in neurons and glia, signal transduction. |
W. Glenn Kerrick
Professor |
|
Regulation of contractile protein interactions. Contractile processes involving the cytoskeleton. Use of permeabilized cells to simultaneously measure the mechanical parameter of muscle contraction and parameters such as Ca2+ binding to regulatory proteins, protein-protein interactions myosin light-chain phosphorylation, and energy usage. |
David Landowne
Professor |
|
Changes in the optical properties of nerves during the passage of nerve impulses. Gating currents. Voltage-clamped squid giant axons. |
Karl Magleby
Professor and Chair |
|
Molecular mechanisms by which ion channels open and close their pores (gating) and allow the passage of ions (conductance and selectivity). The mechanism of short-term synaptic plasticity. Computer recording and analysis of the data and the development of kinetic models provide the experimental framework for the studies. |
Vincent Moy
Associate Professor |
|
Force spectroscopy, atomic force microscopy, molecular and cell adhesion, cell mechanics, biophysics. www.vmoy.net. |
Kenneth Muller
Professor |
|
How nerve cells form precise synaptic connections with one another and how those connections normally function. Axon growth and repair. Electrophysiology, cell marking, laser microsurgery, in situ hybridization and electron microscopy. |
Wolfgang Nonner
Professor |
|
What physics make ion channels conduct ions selectively and control their ionic pathway? Computational analysis of key structural elements by particle simulation, development of theory relating atomic structure to physiological function. |
Stephen Roper
Professor |
|
Cellular and molecular biology of chemosensory transduction in taste buds. patch clamp and intracellular microelectrode recordings, light and electron microscopy, immunocytochemistry, image analysis, in situ hybridization. |
