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Eric L. Greidinger, M.D.

General Information

Eric L. Greidinger, M.D.


  • Fax: 305-243-7546


  • Internal Medicine
  • Rheumatology-Internal Medicine



Clinical Areas

Mixed Connective Tissue Disease



Systemic lupus erythematosis


  • American Board of Internal Medicine
  • American Board of Internal Med-Rheumatology


  • Chief, Division of Rheumatology

Research Interests


Innate immunity

Tissue targeting

Programmed cell death

Pathogenesis of disease in scleroderma

SLE and mixed connective tissue disease.


  • Carpintero MF, Martinez L, Fernandez I, Romero AC, Mejia C, Zang YJ, Hoffman RW, Greidinger EL. Diagnosis and risk stratification in patients with anti-RNP autoimmunity. Lupus. 2015 Mar 2. pii: 0961203315575586. [Epub ahead of print]
  • Zang Y, Martinez L, Fernandez I, Pignac-Kobinger J, Greidinger EL. Conservation of pathogenic TCR homology across class II restrictions in anti-ribonucleoprotein autoimmunity: extended efficacy of T cell vaccine therapy. J Immunol. 2014 May 1;192(9):4093-102.
  • Greidinger EL, Hoffman RW. Mixed Connective-Tissue Disease. Medscape Reference. Updated December 16, 2014.
  • Mesa A, Somarelli JA, Wu W, Martinez L, Blom MB, Greidinger EL, Herrera RJ. Differential immunoglobulin class-mediated responses to components of the U1 small nuclear ribonucleoprotein particle in systemic lupus erythematosus and mixed connective tissue disease. Lupus. 2013 Nov;22(13):1371-81
  • Bernard JJ, Cowing-Zitron C, Nakatsuji T, Muehleisen B, Muto J, Borkowski AW, Martinez L, Greidinger EL, Yu BD, Gallo RL. Ultraviolet radiation damages self noncoding RNA and is detected by TLR3. Nat Med. 2012 Aug;18(8):1286-90.
  • Trivedi S, Zang Y, Culpepper S, Rosenbaum E, Fernandez I, Martinez L, Hoffman RW, Greidinger EL. T cell vaccination therapy in an induced model of anti-RNP autoimmune glomerulonephritis. Clin Immunol. 2010 Nov;137(2):281-7.
  • Greidinger EL, Zang Y, Fernandez I, Berho M, Nassiri M, Martinez L, Hoffman RW. Tissue targeting of anti-RNP autoimmunity: effects of T cells and myeloid dendritic cells in a murine model. Arthritis Rheum. 2009 Feb;60(2):534-42.


Stanley J. Glaser Research Award
Wolstenholm Memorial Fellow, Arthritis National Research Foundation
Einbender Memorial Lectureship in Lupus Research


1997 Fellowship
John Hopkins University
1994 Residency
University of Michigan
1991 Graduate
University of Michigan
1987 Undergraduate
Princeton University


Chief of the Division of Rheumatology Eric L. Greidinger, M.D. is an expert in Mixed Connective Tissue Disease and related rheumatic overlap syndromes. Continuously funded by federal peer reviewed grants for over 14 years, Dr. Greidinger's research interests include the tissue targeting of autoimmunity and the pathobiology of Raynaud's Phenomenon. 

At UM, Dr. Greidinger has made major discoveries regarding the roles of the innate immune system in the pathogenesis of lupus and related conditions, and has developed major new animal models of Mixed Connective Tissue Disease and Raynaud's Phenomenon.  As Division Chief, Dr. Greidinger has pioneered the development of the Rheumatology Intake Clinics to speed access to rheumatology services to new patients, grown subspecialty programs in the rheumatic diseases that leverage the world/renowned expertise of our rheumatology faculty, and overseen a quadrupling of the number of funded research studies ongoing by rheumatology faculty.

Dr. Greidinger is a member of the Cancer Center at UM. He serves on the Research and Development and Scientific Review Committees at the Miami VA Medical Center. He serves on numerous scientific review panels, Including for the NIH, VA, Arthritis Foundation, and Lupus Research Institute. 

Dr. Greidinger is board-certified in Rheumatology and Internal Medicine.

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